RESUMO
Anti-α-Gal responses may exert a protective effect in falciparum malaria. However, the biological role of such antibodies is still unknown during Plasmodium vivax infections. We investigated IgG and IgM responses to α-Gal in individuals with vivax malaria. Anti-α-Gal IgG and IgM levels were higher in these patients than in controls, but no significant correlation was found between parasitaemia and anti-α-Gal response, nor between this response and ABO blood group status. This is the first study to investigate anti-α-Gal antibodies in P. vivax-infected patients; a larger survey is necessary to achieve a better understanding of host immune response during vivax malaria.
Assuntos
Anticorpos Anti-Idiotípicos/sangue , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Malária Vivax/sangue , Plasmodium vivax/imunologia , Adulto , Anticorpos Anti-Idiotípicos/metabolismo , Humanos , Imunoglobulina G/imunologia , Imunoglobulina M/imunologia , Malária Vivax/imunologia , Pessoa de Meia-Idade , Adulto JovemRESUMO
Anti-α-Gal responses may exert a protective effect in falciparum malaria. However, the biological role of such antibodies is still unknown during Plasmodium vivax infections. We investigated IgG and IgM responses to α-Gal in individuals with vivax malaria. Anti-α-Gal IgG and IgM levels were higher in these patients than in controls, but no significant correlation was found between parasitaemia and anti-α-Gal response, nor between this response and ABO blood group status. This is the first study to investigate anti-α-Gal antibodies in P. vivax-infected patients; a larger survey is necessary to achieve a better understanding of host immune response during vivax malaria.
